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Three types of PC deficiency have been distinguished: type A (infantile PC deficiency), type B (referred to as severe neonatal PC deficiency) and the less common type C (referred to as intermittent or mild PC deficiency)

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In terms of iron metabolism and homeostasis in immune cells, a study revealed that iron overload promotes abnormal differentiation of pathogenic T cells, including follicular helper T cells, by regulating DNA demethylation, thus exacerbating autoantibody production and the development of systemic lupus erythematosus (SLE) [26]